5 Essential Elements For methadone erectile dysfunction treatment
[61] Like quite a few other cardiotoxic drugs, methadone blocks the hERG K+ channel. The two enantiomers of methadone inhibit hERG channels with unique potency. Dextromethadone, which is a lot less powerful as an opioid, is much more powerful at blocking the hERG channel with an IC50 of ~12 μM. Levomethadone contains a lower affinity, with an IC50